Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies

Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies

Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system incl...

Autoimmune neuropathies and treatment with intravenous immunoglobulins

Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses

Intravenous immunoglobulins (IVIGs), a mixture of variable amounts of proteins (albumin, IgG, IgM, IgA, and IgE antibodies), as well as salt, sugar, solvents, and detergents, are successfully used to treat a variety of dermatological disorders. For decades, IVIGs have been administered for treatment of infectious diseases and immune deficiencies, since they contain natural antibodies that repre...

Three cases of systemic lupus erythematosus and review of the mechanisms concerning treatment with intravenous immunoglobulins (IVIG).

The systemic lupus erythematosus (SLE) is an autoimmune disorder with a broad array of clinical signs. In this research, we aimed to use intravenous immunoglobulins (IVIG) called intacglobin as monotherapy to manage an SLE in three patients. Laboratory investigations for SLE diagnosis were done, including the detection of anti-nuclear antibodies (ANA) and SLE confirmation by detecting high tite...

Intravenous Immunoglobulins Lower Inflammatory Gene Expression in Skin Biopsies of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients.

according to CIDP Disease Activity Status (CDAS) [4, 6] . Twelve healthy volunteers were used as controls (‘Ctrl’ group). Skin punch biopsies were performed 10 cm above the external malleoli and snap frozen in liquid nitrogen. RNA extraction, gene expression profiling, and MetaCore ® data analysis were performed according to the methods described previously [4] with the following filters: fold ...